TNKS2 anticorps (AA 780-1050)

N° du produit ABIN7270726

Détail du produit anti-TNKS2 anticorps

Antigène: TNKS2 (Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2))

Épitope: AA 780-1050

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TNKS2 est non-conjugé

Application: Western Blotting (WB)

Fonction: TNKS2 Rabbit pAb

Séquence: TPLDLVSADD VSALLTAAMP PSALPSCYKP QVLNGVRSPG ATADALSSGP SSPSSLSAAS SLDNLSGSFS ELSSVVSSSG TEGASSLEKK EVPGVDFSIT QFVRNLGLEH LMDIFEREQI TLDVLVEMGH KELKEIGINA YGHRHKLIKG VERLISGQQG LNPYLTLNTS GSGTILIDLS PDDKEFQSVE EEMQSTVREH RDGGHAGGIF NRYNILKIQK VCNKKLWERY THRRKEVSEE NHNHANERML FHGSPFVNAI IHKGFDERHA Y

Réactivité croisée: Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 780-1050 of human TNKS2 (NP_079511.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur TNKS2

Antigène: TNKS2 (Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2))

Autre désignation: TNKS2 (TNKS2 Produits)

Synonymes: anticorps ARTD6, anticorps PARP-5b, anticorps PARP-5c, anticorps PARP5B, anticorps PARP5C, anticorps TANK2, anticorps TNKL, anticorps pART6, anticorps 5430432P15Rik, anticorps AA517131, anticorps AI662480, anticorps TNKS-2, anticorps Tank2, anticorps tankyrase-2, anticorps TNKS2, anticorps tankyrase-1, anticorps tnks, anticorps tnks.L, anticorps tnks2, anticorps tankyrase 2, anticorps tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2, anticorps tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase S homeolog, anticorps TNKS2, anticorps Tnks2, anticorps tnks2, anticorps tnks.S

Sujet: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. Stimulates 26S proteasome activity.,TNKS2,ARTD6,PARP-5b,PARP-5c,PARP5B,PARP5C,TANK2,TNKL,pART6,Epigenetics & Nuclear Signaling,Signal Transduction,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,Wnt/β-Catenin Signaling Pathway,TNKS2

Poids moléculaire: 126kDa

ID gène: 80351

UniProt: Q9H2K2