TMED2 anticorps (AA 60-170)

N° du produit ABIN7270943

Détail du produit anti-TMED2 anticorps

Antigène: TMED2 (Transmembrane Emp24 Domain Trafficking Protein 2 (TMED2))

Épitope: AA 60-170

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TMED2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Fonction: TMED2 Rabbit pAb

Séquence: EITGPDNKGI YKGDRESSGK YTFAAHMDGT YKFCFSNRMS TMTPKIVMFT IDIGEAPKGQ DMETEAHQNK LEEMINELAV AMTAVKHEQE YMEVRERIHR AINDNTNSRV V

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 60-170 of human TMED2 (NP_006806.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur TMED2

Antigène: TMED2 (Transmembrane Emp24 Domain Trafficking Protein 2 (TMED2))

Autre désignation: TMED2 (TMED2 Produits)

Synonymes: anticorps P24A, anticorps RNP24, anticorps p24, anticorps 1110032D12Rik, anticorps 1810020N21Rik, anticorps Rnp24, anticorps Sid394, anticorps p24beta1, anticorps Chop24, anticorps transmembrane p24 trafficking protein 2, anticorps TMED2, anticorps Tmed2

Sujet: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor, the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs. Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing.,P24A,RNP24,p24,p24b1,p24beta1,TMED2,Signal Transduction,Cell Biology & Developmental Biology,TMED2

Poids moléculaire: 22kDa

ID gène: 10959

UniProt: Q15363