USP18 anticorps (AA 200-300)

N° du produit ABIN7271145

Détail du produit anti-USP18 anticorps

Antigène: USP18 (Ubiquitin Specific Peptidase 18 (USP18))

Épitope: AA 200-300

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp USP18 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)

Fonction: USP18 Rabbit pAb

Séquence: DVDSKPLKTL EDALHCFFQP RELSSKSKCF CENCGKKTRG KQVLKLTHLP QTLTIHLMRF SIRNSQTRKI CHSLYFPQSL DFSQILPMKR ESCDAEEQSG G

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 200-300 of human USP18 (NP_059110.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur USP18

Antigène: USP18 (Ubiquitin Specific Peptidase 18 (USP18))

Autre désignation: USP18 (USP18 Produits)

Synonymes: anticorps ISG43, anticorps UBP43, anticorps bubp43, anticorps 1110058H21Rik, anticorps AW047653, anticorps Ubp15, anticorps UBP, anticorps USP18, anticorps USP41, anticorps ubiquitin specific peptidase 18, anticorps USP18, anticorps Usp18

Sujet: The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15.,USP18,ISG43,UBP43,PTORCH2,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Ubiquitin,USP18

Poids moléculaire: 43kDa

ID gène: 11274

UniProt: Q9UMW8