XBP1 anticorps (AA 300-376)

N° du produit ABIN7271399

Détail du produit anti-XBP1 anticorps

Antigène: XBP1 (X-Box Binding Protein 1 (XBP1))

Épitope: AA 300-376

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp XBP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Fonction: XBP1s Rabbit pAb

Séquence: SVKEEPVEDD LVPELGISNL LSSSHCPKPS SCLLDAYSDC GYGGSLSPFS DMSSLLGVNH SWEDTFANEL FPQLISV

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: A synthetic peptide corresponding to a sequence within amino acids 300-376 of human XBP1s (NP_001073007.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur XBP1

Antigène: XBP1 (X-Box Binding Protein 1 (XBP1))

Autre désignation: XBP1 (XBP1 Produits)

Synonymes: anticorps treb5, anticorps xXBP1, anticorps xbp2, anticorps XBP1P1, anticorps XBPP1, anticorps xbp1, anticorps TREB5, anticorps XBP-1, anticorps XBP2, anticorps D11Ertd39e, anticorps TREB-5, anticorps HTF, anticorps cb918, anticorps id:ibd1195, anticorps trebf, anticorps wu:fb02h05, anticorps wu:fb63f10, anticorps xbp1a, anticorps xbp1b, anticorps X-box binding protein 1, anticorps X-box binding protein 1 L homeolog, anticorps xbp1, anticorps XBP1, anticorps Xbp1, anticorps xbp1.L

Sujet: This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.,XBP1,TREB-5,TREB5,XBP-1,XBP2,XBP1s,CBX1,Epigenetics & Nuclear Signaling,Transcription Factors,XBP1

Poids moléculaire: 28kDa/40kDa

ID gène: 7494

UniProt: P17861

Pathways: ER-Nucleus Signaling, Unfolded Protein Response