Coronavirus Spike Glycoprotein anticorps

N° du produit ABIN7383834

Détail du produit anti-Coronavirus Spike Glycoprotein anticorps

Antigène: Coronavirus Spike Glycoprotein (CoV S)

Reactivité: Human Coronavirus HKU1 (HCoV-HKU1)

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Coronavirus Spike Glycoprotein est non-conjugé

Application: ELISA

Specificité: Anti-Human coronavirus spike glycoprotein Monoclonal Antibody

Purification: Protein A Affinity

Immunogène: Recombinant HCoV-HKU1 (Isolate N1) S1 Protein (His Tag), ABIN7198827

Clone: 28

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:5000-1:10000

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: 0.2 μm filtered solution in PBS

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur Coronavirus Spike Glycoprotein

Antigène: Coronavirus Spike Glycoprotein (CoV S)

Autre désignation: coronavirus spike glycoprotein (CoV S Produits)

Synonymes: anticorps E2, anticorps E2 glycoprotein precursor, anticorps S

Classe de substances: Viral Protein

Sujet: Spike,The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, dipeptidyl peptidase-4, APN, aminopeptidase N, CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1, Sia, sialic acid, O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that SARS-CoV-2 (COVID-19 coronavirus, 2019-nCoV) can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion, Defines the range of the hosts and specificity of the virus, Main component to bind with the neutralizing antibody, Key target for vaccine design, Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.