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ZEBOV GP anticorps

ZEBOV GP Reactivité: Zaire ebolavirus ELISA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7383906
  • Antigène Tous les produits ZEBOV GP
    ZEBOV GP (Zaire Ebola Virus Envelope Glycoprotein (ZEBOV GP))
    Reactivité
    Zaire ebolavirus
    Hôte
    • 1
    • 1
    Lapin
    Clonalité
    • 1
    • 1
    Polyclonal
    Conjugué
    • 2
    Cet anticorp ZEBOV GP est non-conjugé
    Application
    • 2
    • 1
    ELISA
    Specificité
    Anti-Ebola virus EBOV(subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) Glycoprotein/GP Polyclonal Antibody
    Purification
    Antigen Affinity
    Immunogène
    Recombinant EBOV (subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) Glycoprotein / GP Protein (His Tag), ABIN7198910
    Isotype
    IgG
  • Indications d'application
    ELISA 1:5000-1:10000
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    0.2 μm filtered solution in PBS
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    ZEBOV GP (Zaire Ebola Virus Envelope Glycoprotein (ZEBOV GP))
    Autre désignation
    ZEBOV Glycoprotein/GP (ZEBOV GP Produits)
    Sujet
    Glycoprotein,GP,The fourth gene of the EBOV genome encodes a 16- kDa envelope-attached glycoprotein (GP) and a 11 kDa secreted glycoprotein (sGP). Both GP and sGP have an identical 295-residue N-terminus, however, they have different C-terminal sequences. Recently, great attention has been paid to GP for vaccines design and entry inhibitors isolation. GP is a class I fusion protein which assembles as trimers on viral surface and plays an important role in virus entry and attachment. Mature GP is a disulfide-linked heterodimer formed by two subunits, GP1 and GP2, which are generated from the proteolytical process of GP precursor (pre-GP) by cellular furin during virus assembly . The GP1 subunit contains a mucin domain and a receptor-binding domain (RBD), the GP2 subunit has a fusion peptide, a helical heptad-repeat (HR) region, a transmembrane (TM) domain, and a 4-residue cytoplasmic tail. The RBD of GP1 mediates the interaction of EBOV with cellular receptor (e.g. DC-SIGN/LSIGN, TIM-1, hMGL, NPC1, β-integrins, folate receptor-α, and Tyro3 family receptors), of which TIM1 and NPC1 are essential for EBOV entry, the mucin domain having N- and O-linked glycans enhances the viral attachment to cellular hMGL, and participates in shielding key neutralization epitopes, which helps the virus evades immune elimination. There are large conformation changes of GP2 during membrane fusion, which enhance the insertion of fusion loop into cellular membrane and facilitate the release of viral nucleocapsid core to cytoplasm.
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