LRP8 anticorps
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- Antigène Voir toutes LRP8 Anticorps
- LRP8 (Low Density Lipoprotein Receptor-Related Protein 8, Apolipoprotein E Receptor (LRP8))
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Reactivité
- Humain, Rat, Hamster
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Hôte
- Lapin
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp LRP8 est non-conjugé
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Application
- Western Blotting (WB)
- Purification
- Affinity Purified
- Clone
- R03-1H8
- Isotype
- IgG
- Top Product
- Discover our top product LRP8 Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000
- Restrictions
- For Research Use only
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- Concentration
- 300 μg/mL
- Buffer
- 50 mM Tris-Glycine( pH 7.4), 0.15M NaCl, 40 % Glycerol, 0.01 % Sodium azide and 0.05 % BSA
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Avoid freeze / thaw cycles.
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- Antigène
- LRP8 (Low Density Lipoprotein Receptor-Related Protein 8, Apolipoprotein E Receptor (LRP8))
- Autre désignation
- ApoER2 (LRP8 Produits)
- Synonymes
- anticorps LRP8, anticorps APOER2, anticorps HSZ75190, anticorps LRP-8, anticorps MCI1, anticorps 4932703M08Rik, anticorps AA921429, anticorps AI848122, anticorps ApoER2, anticorps Lr8b, anticorps LR8B, anticorps LDL receptor related protein 8, anticorps low density lipoprotein receptor-related protein 8, apolipoprotein e receptor, anticorps LRP8, anticorps Lrp8
- Sujet
- MCI1,LRP-8,APOER2,HSZ75190,Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor. Not required for endocytic uptake of SEPP1 in the kidney which is mediated by LRP2 . Together with its ligand, apolipoprotein E (apoE), may indirectly play a role in the suppression of the innate immune response by controlling the survival of myeloid-derived suppressor cells .
- Poids moléculaire
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Observed_MW: 106kDa
Calculated_MW: 106kDa
- ID gène
- 7804
- UniProt
- Q14114
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