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APEX2 anticorps (AA 301-400)

APEX2 Reactivité: Rat, Souris WB, ELISA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN718481
  • Antigène Voir toutes APEX2 Anticorps
    APEX2 (APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2))
    Épitope
    • 7
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 301-400
    Reactivité
    Rat, Souris
    Hôte
    • 20
    • 2
    Lapin
    Clonalité
    • 22
    Polyclonal
    Conjugué
    • 12
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp APEX2 est non-conjugé
    Application
    • 20
    • 15
    • 14
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA
     Réactivité croisée
    Souris, Rat
    Homologie
    Human
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human APEX2
    Isotype
    IgG
    Top Product
    Discover our top product APEX2 Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Antigène
    APEX2 (APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2))
    Autre désignation
    APEX2 (APEX2 Produits)
    Synonymes
    anticorps APE2, anticorps APEXL2, anticorps XTH2, anticorps ape2, anticorps apexl2, anticorps xth2, anticorps zgc:55889, anticorps C430040P13Rik, anticorps apurinic/apyrimidinic endodeoxyribonuclease 2, anticorps APEX nuclease (apurinic/apyrimidinic endonuclease) 2, anticorps apurinic/apyrimidinic endodeoxyribonuclease 2 L homeolog, anticorps apurinic/apyrimidinic endonuclease 2, anticorps APEX2, anticorps apex2, anticorps apex2.L, anticorps Apex2
    Sujet

    Synonyms: APE2, XTH2, ZGRF2, APEXL2, DNA-(apurinic or apyrimidinic site) lyase 2, AP endonuclease XTH2, APEX nuclease 2, APEX nuclease-like 2, Apurinic-apyrimidinic endonuclease 2, AP endonuclease 2, APEX2

    Background: Function as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes.

    ID gène
    27301
    UniProt
    Q9UBZ4
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