TDP1 anticorps (AA 1-50)
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- Antigène Voir toutes TDP1 Anticorps
- TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))
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Épitope
- AA 1-50
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp TDP1 est non-conjugé
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Application
- Immunohistochemistry (IHC)
- Fonction
- Rabbit anti-TDP1 IHC Antibody, Affinity Purified
- Homologie
- Orangutan,Gorilla,Chimpanzee
- Purification
- Affinity Purified
- Immunogène
- Between AA 1 and 50
- Isotype
- IgG
- Top Product
- Discover our top product TDP1 Anticorps primaire
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- Indications d'application
- 1:100 - 1:500
- Restrictions
- For Research Use only
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- Concentration
- 250 μg/mL
- Buffer
- Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Date de péremption
- 12 months
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- Antigène
- TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))
- Autre désignation
- TDP1 (TDP1 Produits)
- Synonymes
- anticorps 2810481F14Rik, anticorps 4921509N21Rik, anticorps AI838772, anticorps AW493413, anticorps E430034L06Rik, anticorps MLZ-501, anticorps SCAN1, anticorps tdp1, anticorps MGC83708, anticorps TDP1, anticorps F8M21.60, anticorps F8M21_60, anticorps tyrosyl-DNA phosphodiesterase 1, anticorps tyrosyl-DNA phosphodiesterase 1, anticorps tyrosyl-DNA Phosphodiesterase (Tdp1), anticorps tyrosyl-DNA phosphodiesterase 1 L homeolog, anticorps tyrosyl-DNA phosphodiesterase-like protein, anticorps TDP1, anticorps Tc00.1047053511191.10, anticorps Tdp1, anticorps tdp1.L, anticorps tdp1, anticorps PTRG_11198, anticorps MCYG_02121, anticorps MGYG_03035
- Sujet
- Background: Tyrosyl-DNA phosphodiesterase 1 (TDP1) is an enzyme that participates in the repair of DNA strand breaks associated with topoisomerase 1 (Top1) complexes. TDP1 catalyzes the removal of Top1 from DNA via the hydrolysis of the phosphodiester bond between the tyrosine residue of Top1 and the 3' phosphate of DNA. Removal of Top1 is then followed by DNA repair. TDP1 has been proposed to play more general roles in DNA damage repair independent of the Top1 complex. TDP1 has been shown to associate with DNA ligase IIIalpha, a component of the DNA single-stranded break repair (SSBR) machinery. It is also able to remove glycolate from 3'-phosphoglycolate termini of double-stranded breaks and a variety of other 3'- adducts. Defects in TDP1 are associated with spinocerebellar ataxia autosomal recessive with axonal neuropathy (SCAN1), a disease associated with peripheral axonal motor and sensory neuropathy and distal muscular atrophy.
- ID gène
- 55775
- NCBI Accession
- NP_001008744
- UniProt
- Q9NUW8
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