anticorps NHEJ1, anticorps zgc:85657, anticorps XLF, anticorps 1700029B21Rik, anticorps cernunnos, anticorps non-homologous end joining factor 1, anticorps non-homologous end joining factor 1 S homeolog, anticorps solute carrier family 23 member 3, anticorps nonhomologous end-joining factor 1, anticorps NHEJ1, anticorps nhej1.S, anticorps nhej1, anticorps SLC23A3, anticorps Nhej1
Sujet
Background: XRCC4-like factor (XLF) functions in DNA nonhomologous end joining (NHEJ) in double-strand break repair and immune system V(D)J recombination. Mutations of XLF in humans have been documented to result in immunodeficiency, growth retardation, and microcephaly. The yeast of homolog of XLF is Nej1. XLF has been shown to interact with the XRCC4 x DNA-ligase IV complex and is implicated in the DNA religation step of the NHEJ pathway.