RRAGA anticorps (AA 544-594)

N° du produit ABIN7448966

Détail du produit anti-RRAGA anticorps

Antigène: RRAGA (Ras-Related GTP Binding A (RRAGA))

Épitope: AA 544-594

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RRAGA est non-conjugé

Application: Immunohistochemistry (IHC), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Fonction: Rabbit anti-FIP1 IHC Antibody, Affinity Purified

Homologie: Bovine,Horse,Pig,Orangutan,Monkey,Gorilla,Chimpanzee,White-tufted-ear marmoset,Northern white-cheeked gibbon,Tasmanian devil

Purification: Affinity Purified

Immunogène: Between AA 544 and 594

Isotype: IgG

Information d'application

Indications d'application:

IHC-IF: 1:50 - 1:500

IHC: 1:100 - 1:500

Restrictions: For Research Use only

Stockage

Concentration: 100 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur RRAGA

Antigène: RRAGA (Ras-Related GTP Binding A (RRAGA))

Autre désignation: FIP1 (RRAGA Produits)

Synonymes: anticorps FIP-1, anticorps FIP1, anticorps RAGA, anticorps 1300010C19Rik, anticorps AI255374, anticorps Raga, anticorps Ras related GTP binding A, anticorps Ras-related GTP binding A, anticorps RRAGA, anticorps Rraga

Sujet: Background: FIP1 was originally identified as Rhe (rearranged in hypereosinophilia) and part of a fusion protein encoded by a genetic rearrangement between the N-terminal region of FIP1 (Rhe) and the C-terminal region of the platelet-derived growth factor receptor alpha (PDGFRalpha). The fusion protein exhibits aberrant tyrosine kinase activity and is associated with hypereosinophilic syndrome (HES), a rare hematologic disorder characterized by an overproduction of eosinophils that results in organ damage. FIP1 was also identified as FIP1-like 1 in a database search for a human homolog of the yeast Fip1p (factor interacting with PAP), a subunit of the yeast 3'-end processing complex, CPF (cleavage and polyadenylation factor). Human FIP1 was similarly found to interact with PAP and CPSF160 as part of the human CPSF (cleavage and polyadenylation specificity factor) complex. In association with CPSF160, FIP1 is able to recognize U-rich elements on pre-mRNA and stimulate PAP activity.

ID gène: 81608

NCBI Accession: NP_112179

UniProt: Q6UN15