FAM105B anticorps (AA 302-352)

N° du produit ABIN7449067

Détail du produit anti-FAM105B anticorps

Antigène: FAM105B (Family with Sequence Similarity 105, Member B (FAM105B))

Épitope: AA 302-352

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FAM105B est non-conjugé

Application: Immunoprecipitation (IP)

Fonction: Rabbit anti-OTULIN Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: between AA 302 and 352

Isotype: IgG

Information d'application

Indications d'application: 15-20 μL/mg lysate

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur FAM105B

Antigène: FAM105B (Family with Sequence Similarity 105, Member B (FAM105B))

Autre désignation: OTULIN (FAM105B Produits)

Synonymes: anticorps C79097, anticorps OTU deubiquitinase with linear linkage specificity, anticorps OTULIN, anticorps Otulin

Sujet: Background: Otulin is a deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex. Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex. OTULIN function is mainly restricted to homeostasis of the LUBAC complex: acts by removing 'Met-1'-linked autoubiquitination of the LUBAC complex, thereby preventing inactivation of the LUBAC complex. Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis. In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation. Plays a role in innate immune response by restricting linear polyubiquitin formation on LUBAC complex in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling. [taken from the Universal Protein Resource (UniProt) Q96BN8].

ID gène: 90268

UniProt: Q96BN8