Apo-B100 anticorps

N° du produit ABIN7449339

Détail du produit anti-Apo-B100 anticorps

Antigène: Apo-B100 (Apoprotein B100 (Apo-B100))

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp Apo-B100 est non-conjugé

Application: Western Blotting (WB), ELISA

Fonction: Goat anti-Human Apo B-100 [A07] Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: Human Apolipoprotein B100

Clone: A07

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:1,000 - 1:80,000

ELISA: 1:1,000 - 1:80,000

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: 75 mM Sodium Phosphate, 75 mM NaCl, 0.5 mM EDTA, 0.02 % Sodium azide, pH 7.2

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur Apo-B100

Antigène: Apo-B100 (Apoprotein B100 (Apo-B100))

Autre désignation: ApoB-100 (Apo-B100 Produits)

Synonymes: anticorps Ac1-060, anticorps Apo B-100, anticorps ApoB-100, anticorps ApoB-48, anticorps apolipoprotein B, anticorps Apob

Sujet: Background: ApoB exists in human plasma in two isoforms, ApoB-48 (Chen et al., 1987) and Apo B-100 (Wei et al., 1985, Yang et al., 1986a, 1989a,b, 1990, Chen et al., 1986, Yang et al., 1990, Yang and Pownall, 1992). Apo B-100 is the major physiological ligand for the LDL receptor. Apo B-100 is a large monomeric protein, containing 4536 amino acids (m.w. 515 kDa, Yang et al., 1986b). Apo B-100 is synthesized in the liver and is required for the assembly of VLDL. It is found in LDL and VLDL after the removal of the Apo A, E and C. Apo B-48 is present in chylomicrons and their remnants. It is essential for the intestinal absorption of dietary lipids. Apo B levels correlate with the risk of coronary disease. The Apo B protein is directly involved in the retention of LDL with the arterial wall (Olofsson and Boren, 2012). Apo B-48 is synthesized in the small intestine. It comprises approximately half of the N-terminal region of ApoB-100 and is the result of posttranscriptional mRNA editing by a stop codon in the intestine not found in the liver.

ID gène: 338

NCBI Accession: NP_000375

UniProt: P04114