Claspin anticorps (AA 900-950)
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- Antigène Voir toutes Claspin (CLSPN) Anticorps
- Claspin (CLSPN)
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Épitope
- AA 900-950
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Claspin est non-conjugé
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Application
- Western Blotting (WB), Immunoprecipitation (IP)
- Fonction
- Rabbit anti-Claspin Antibody, Affinity Purified
- Purification
- Affinity Purified
- Immunogène
- between AA 900 and 950
- Isotype
- IgG
- Top Product
- Discover our top product CLSPN Anticorps primaire
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- Indications d'application
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IP: 2 - 10 μg/mg lysate
WB: 1:1,000 - 1:10,000
- Restrictions
- For Research Use only
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- Concentration
- 1000 μg/mL
- Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Date de péremption
- 12 months
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- Antigène
- Claspin (CLSPN)
- Autre désignation
- Claspin (CLSPN Produits)
- Synonymes
- anticorps CLSPN, anticorps xClaspin, anticorps B130025E01, anticorps C85083, anticorps E130314M08Rik, anticorps claspin, anticorps claspin S homeolog, anticorps Clspn, anticorps CLSPN, anticorps clspn, anticorps clspn.S
- Sujet
- Background: Claspin is a checkpoint protein that interacts with and regulates checkpoint kinase 1 (Chk1) in response to replication stress. The interaction between claspin and Chk1 has been demonstrated to be required for ATR-dependent Chk1 activation. The interaction involves the phosphorylation of claspin that may be accomplished by Chk1 kinase activity. Claspin has been found to localize to chromatin in both the presence and absence of damaged DNA and to associate with PCNA, as an essential component of the DNA replication machinery. This association with the replication machinery may indicate a role for claspin in linking replication to DNA damage signaling and Chk1 activation.
- ID gène
- 63967
- UniProt
- Q9HAW4
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