IWS1 anticorps (AA 1-50)

N° du produit ABIN7449756

Détail du produit anti-IWS1 anticorps

Antigène: IWS1 (IWS1 Homolog (IWS1))

Épitope: AA 1-50

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IWS1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Fonction: Rabbit anti-IWS1 Antibody, Affinity Purified

Homologie: Rat

Purification: Affinity Purified

Immunogène: Between AA 1 and 50

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 10 μg/mg lysate

WB: 1:1,000 - 1:5,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur IWS1

Antigène: IWS1 (IWS1 Homolog (IWS1))

Autre désignation: IWS1 (IWS1 Produits)

Synonymes: anticorps 1700069O15Rik, anticorps 3000008H23, anticorps AL117927, anticorps AW214353, anticorps RGD1304762, anticorps IWS1, SUPT6H interacting protein, anticorps IWS1, SUPT6 interacting protein, anticorps IWS1, anticorps Iws1

Sujet: Background: IWS1 homolog is a transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. IWS1 acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription [taken from the Universal Protein Resource (UniProt) Q96ST2].

ID gène: 55677

NCBI Accession: NP_060439

UniProt: Q96ST2