Stim2 anticorps (AA 650-700)

N° du produit ABIN7449833

Détail du produit anti-Stim2 anticorps

Antigène: Stim2 (Stromal Interaction Molecule 2 (Stim2))

Épitope: AA 650-700

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Stim2 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Fonction: Rabbit anti-STIM2 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: Between AA 650 and 700

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 10 μg/mg lysate

WB: 1:1,000 - 1:5,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur Stim2

Antigène: Stim2 (Stromal Interaction Molecule 2 (Stim2))

Autre désignation: STIM2 (Stim2 Produits)

Synonymes: anticorps STIM2, anticorps stromal interaction molecule 2, anticorps STIM2, anticorps stim2, anticorps Stim2

Sujet: Background: STIM2 (stromal interaction molecule 2) plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Stim2 functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. It regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, STIM2 translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI. STIM2 may inhibit STIM1-mediated Ca(2+) influx  [taken from the Universal Protein Resource (UniProt) Q9P246].

ID gène: 57620

NCBI Accession: NP_065911

UniProt: Q9P246

Pathways: TCR Signaling, BCR Signaling