PAN3 anticorps (AA 175-225)

N° du produit ABIN7450539

Détail du produit anti-PAN3 anticorps

Antigène: PAN3 (PAN3 Poly(A) Specific Ribonuclease Subunit Homolog (PAN3))

Épitope: AA 175-225

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PAN3 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Fonction: Rabbit anti-PAN3 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: Between AA 175 and 225

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur PAN3

Antigène: PAN3 (PAN3 Poly(A) Specific Ribonuclease Subunit Homolog (PAN3))

Autre désignation: PAN3 (PAN3 Produits)

Synonymes: anticorps 2700050F09Rik, anticorps A430027N15Rik, anticorps AU014670, anticorps pan3, anticorps zgc:171628, anticorps PAN3 poly(A) specific ribonuclease subunit, anticorps PAN3 poly(A) specific ribonuclease subunit S homeolog, anticorps PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae), anticorps Pan3, anticorps PAN3, anticorps pan3.S, anticorps pan3

Sujet: Background: PAB-dependent poly(A)-specific ribonuclease subunit PAN3 is a regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with PABP and to miRNA targets via its interaction with GW182 family proteins [taken from the Universal Protein Resource (UniProt) Q58A45].

ID gène: 255967

UniProt: Q58A45