PHLPP2 anticorps (C-Term)

N° du produit ABIN7450565

Détail du produit anti-PHLPP2 anticorps

Antigène: PHLPP2 (PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))

Épitope: C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PHLPP2 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Fonction: Rabbit anti-PHLPPL Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: between AA 1275 and C-term

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur PHLPP2

Antigène: PHLPP2 (PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))

Autre désignation: PHLPPL (PHLPP2 Produits)

Synonymes: anticorps PHLPPL, anticorps phlppl, anticorps AI481772, anticorps C130044A18Rik, anticorps Phlppl, anticorps RGD1562857, anticorps PH domain and leucine rich repeat protein phosphatase 2, anticorps PH domain and leucine rich repeat protein phosphatase 2 S homeolog, anticorps PHLPP2, anticorps phlpp2.S, anticorps phlpp2, anticorps Phlpp2

Sujet: Background: PHLPPL (PH domain leucine-rich repeat-containing protein phosphatase-like) is responsible for the dephosphorylation and subsequent inactivation of Akt. Akt is a signaling protein critical to the balance of cell survival and apoptosis. Dephosphorylation of Akt by PHLPPL has been demonstrated to trigger apoptosis and suppress tumor cell growth. PHLPPL is also known as PHLPPL2 and functions similarly to its relative, PHLPP1. Recent studies show that PHLPPL and PHLPP selectively terminate Akt-signaling by targeting specific Akt isoforms.

ID gène: 23035

NCBI Accession: NP_055835

UniProt: Q6ZVD8

Pathways: Signalisation PI3K-Akt, Fc-epsilon Receptor Signaling Pathway