USP11 anticorps (AA 870-920)

N° du produit ABIN7450882

Détail du produit anti-USP11 anticorps

Antigène: USP11 (Ubiquitin Specific Peptidase 11 (USP11))

Épitope: AA 870-920

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp USP11 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Fonction: Rabbit anti-USP11 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: Between AA 870 and 920

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur USP11

Antigène: USP11 (Ubiquitin Specific Peptidase 11 (USP11))

Autre désignation: USP11 (USP11 Produits)

Synonymes: anticorps USP11, anticorps DKFZp459L098, anticorps UHX1, anticorps 6230415D12Rik, anticorps mKIAA4085, anticorps Uhx1, anticorps ubiquitin specific peptidase 11, anticorps universal stress protein, anticorps USP11, anticorps RR_RS19935, anticorps Usp11

Sujet: Background: Ubiquitin (Ub) is a highly conserved protein found ubiquitously in eukaryotic organisms. The conjugation of ubiquitin to proteins is an important means to regulate protein activity for many cellular processes by tagging them for degradation. Removal of Ub can rescue proteins from degradation. This is accomplished by the ubiquitin-specific processing protease (UBP) family of enzymes. Ubiquitin specific processing protease 11 (USP11) is a member of this family. USP11 has been found to associate with several proteins and may have functions independent of its deubiquitinating activity. USP11 deubiquitinates and associates with the RanGTP-binding protein, RanBPM. It has also been found to associate with BRCA2 and participate in the BRCA2 DNA damage related pathway, however, it does not appear to be involved in BRCA2 deubiquitination. USP11 also appears to play a role in the regulation of the IKKalpha and p53 signaling pathway by a mechanism independent of it deubiquitination activity.

ID gène: 8237

UniProt: P51784