SPEN anticorps (AA 1350-1400)
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- Antigène Voir toutes SPEN Anticorps
- SPEN (Spen Homolog, Transcriptional Regulator (SPEN))
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Épitope
- AA 1350-1400
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp SPEN est non-conjugé
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Application
- Immunoprecipitation (IP)
- Fonction
- Rabbit anti-SHARP Antibody, Affinity Purified
- Homologie
- Mouse
- Purification
- Affinity Purified
- Immunogène
- between AA 1350 and 1400
- Isotype
- IgG
- Top Product
- Discover our top product SPEN Anticorps primaire
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- Indications d'application
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IP: 2 - 10 μg/mg lysate
WB: Not recommended for crude preparations. ABIN7451040 can be used successfully for WB of enriched preparations (e.g. immunoprecipitated) SHARP.
- Restrictions
- For Research Use only
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- Concentration
- 1000 μg/mL
- Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Date de péremption
- 12 months
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- Antigène
- SPEN (Spen Homolog, Transcriptional Regulator (SPEN))
- Autre désignation
- SHARP (SPEN Produits)
- Synonymes
- anticorps HIAA0929, anticorps MINT, anticorps RBM15C, anticorps SHARP, anticorps Mint, anticorps mKIAA0929, anticorps spen family transcriptional repressor, anticorps SPEN homolog, transcriptional regulator (Drosophila), anticorps SPEN, anticorps Spen
- Sujet
- Background: SHARP functions as a transcriptional repressor by interacting with proteins involved in deacetylation such as the NuRD (nucleosome remodeling) complex. SHARP can also repress transcription by interacting with corepressors such as SMRT/NCoR (silencing mediator for retinoid and thyroid receptors/nuclear receptor corepressor). SHARP is able to suppress transcription through the Notch/RBP-J signaling pathway by competing RBP-J binding with the intracellular domain of Notch.
- ID gène
- 23013
- NCBI Accession
- NP_055816
- UniProt
- Q96T58
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