RRP8 anticorps (AA 406-456)

N° du produit ABIN7451332

Détail du produit anti-RRP8 anticorps

Antigène: RRP8 (Ribosomal RNA Processing 8 (RRP8))

Épitope: AA 406-456

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RRP8 est non-conjugé

Application: Immunoprecipitation (IP)

Fonction: Rabbit anti-RRP8 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: Between AA 406 and 456

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 10 μg/mg lysate

WB: Not recommended. Use rabbit anti-RRP8 antibody ABIN7453202.

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur RRP8

Antigène: RRP8 (Ribosomal RNA Processing 8 (RRP8))

Autre désignation: RRP8 (RRP8 Produits)

Synonymes: anticorps KIAA0409, anticorps 1500003O22Rik, anticorps 2900001K19Rik, anticorps AW538116, anticorps RGD1308302, anticorps ribosomal RNA processing 8, anticorps ribosomal RNA processing 8, methyltransferase, homolog (yeast), anticorps RRP8, anticorps Rrp8

Sujet: Background: Ribosomal RNA-processing protein (RRP8) is an essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown [taken from the Universal Protein Resource (UniProt) O43159].

ID gène: 23378

NCBI Accession: NP_056139

UniProt: O43159