UPF3B anticorps (AA 433-483)

N° du produit ABIN7451537

Détail du produit anti-UPF3B anticorps

Antigène: UPF3B (UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B))

Épitope: AA 433-483

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UPF3B est non-conjugé

Application: Immunoprecipitation (IP)

Fonction: Rabbit anti-UPF3B Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: Between AA 433 and 483

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 10 μg/mg lysate

WB: Not recommended

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur UPF3B

Antigène: UPF3B (UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B))

Autre désignation: UPF3B (UPF3B Produits)

Synonymes: anticorps HUPF3B, anticorps MRXS14, anticorps RENT3B, anticorps UPF3X, anticorps 5730594O13Rik, anticorps AI317193, anticorps AW541158, anticorps RGD1560264, anticorps UPF3B, regulator of nonsense mediated mRNA decay, anticorps UPF3 regulator of nonsense transcripts homolog B (yeast), anticorps UPF3B, anticorps Upf3b

Sujet: Background: UPF3B (UPF regulator of nonsense transcripts homolog B) is involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. UPF3B recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2, UPF3B stimulates both ATPase and RNA helicase activities of UPF1 [taken from the Universal Protein Resource (UniProt) Q9BZI7].

ID gène: 65109

NCBI Accession: NP_542199

UniProt: Q9BZI7