SPAG5 anticorps (AA 875-925)

N° du produit ABIN7451646

Détail du produit anti-SPAG5 anticorps

Antigène: SPAG5 (Sperm Associated Antigen 5 (SPAG5))

Épitope: AA 875-925

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPAG5 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Fonction: Rabbit anti-Astrin/MAP126 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: between AA 875 and 925

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur SPAG5

Antigène: SPAG5 (Sperm Associated Antigen 5 (SPAG5))

Autre désignation: Astrin/MAP126 (SPAG5 Produits)

Synonymes: anticorps SPAG5, anticorps DEEPEST, anticorps MAP126, anticorps hMAP126, anticorps AI874642, anticorps D11Bhm180e, anticorps Deepest, anticorps Mastrin, anticorps S17, anticorps sperm associated antigen 5, anticorps sperm-associated antigen 5, anticorps SPAG5, anticorps LOC739263, anticorps Spag5

Sujet: Background: Astrin/MAP126 has been identified as a mitotic spindle-associated protein essential for centrosome integrity and the progression through mitosis. Astrin/MAP126 interacts with Ninein and Aurora-A at the centrosome. Ninein, but not Aurora-A, appears to be required for proper localization of Astrin/MAP126 to the centrosome during S and G2 phase. A pool of Astrin/MAP126 also localizes to the outer kinetochore where it plays an essential role in chromatid adhesion and chromosome congression and segregation. The localization of Astrin/MAP126 to the spindle pole and kinetochore has been shown to be dependent on its phosphorylation by glycogen synthase kinase 3beta (GSK3beta).

ID gène: 10615

NCBI Accession: NP_006452

UniProt: Q96R06

Pathways: M Phase