BRAP anticorps (AA 560-592)

N° du produit ABIN7451664

Détail du produit anti-BRAP anticorps

Antigène: BRAP (BRCA1 Associated Protein (BRAP))

Épitope: AA 560-592

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BRAP est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Fonction: Rabbit anti-BRAP Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: between AA 560 and 592

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur BRAP

Antigène: BRAP (BRCA1 Associated Protein (BRAP))

Autre désignation: BRAP (BRAP Produits)

Synonymes: anticorps imp, anticorps MGC68778, anticorps zgc:92894, anticorps BRAP, anticorps BRAP2, anticorps IMP, anticorps RNF52, anticorps 3010002G07Rik, anticorps BRCA1 associated protein S homeolog, anticorps BRCA1 associated protein, anticorps BRCA1-associated protein, anticorps brca1-associated protein, anticorps brap.S, anticorps brap, anticorps BRAP, anticorps NAEGRDRAFT_81654, anticorps CC1G_00971, anticorps CpipJ_CPIJ003557, anticorps Tsp_05101, anticorps LOC100282389, anticorps Brap

Sujet: Background: BRCA1-associated protein (BRAP) negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. BRAP acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. BRAP may also act as a cytoplasmic retention protein with a role in regulating nuclear transport [taken from the Universal Protein Resource (UniProt) Q7Z569].

ID gène: 8315

NCBI Accession: NP_006759

UniProt: Q7Z569