Mahogunin RING Finger Protein 1 anticorps (AA 400-450)

N° du produit ABIN7451872

Détail du produit anti-Mahogunin RING Finger Protein 1 anticorps

Antigène: Mahogunin RING Finger Protein 1 (MGRN1) (Mahogunin, Ring Finger 1 (MGRN1))

Épitope: AA 400-450

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Mahogunin RING Finger Protein 1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Fonction: Rabbit anti-MGRN1 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: between AA 400 and 450

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur Mahogunin RING Finger Protein 1

Antigène: Mahogunin RING Finger Protein 1 (MGRN1) (Mahogunin, Ring Finger 1 (MGRN1))

Autre désignation: MGRN1 (MGRN1 Produits)

Synonymes: anticorps RNF156, anticorps 2610042J20Rik, anticorps mKIAA0544, anticorps md, anticorps nc, anticorps RGD1311862, anticorps mgrn1, anticorps wu:fi38c03, anticorps zgc:55978, anticorps mahogunin ring finger 1, anticorps mahogunin, ring finger 1, anticorps mahogunin ring finger 1, E3 ubiquitin protein ligase S homeolog, anticorps mahogunin ring finger 1, E3 ubiquitin protein ligase, anticorps mahogunin, ring finger 1a, anticorps MGRN1, anticorps Mgrn1, anticorps mgrn1.S, anticorps mgrn1, anticorps mgrn1a

Sujet: Background: MGRN1 (mahogunin RING finger protein 1) is an E3 ubiquitin-protein ligase that mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. MGRN1 plays a role in the regulation of endosome-to-lysosome trafficking. It impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production but does not promote MC1R ubiquitination [taken from the Universal Protein Resource (UniProt) O60291].

ID gène: 23295

NCBI Accession: NP_001135761

UniProt: O60291

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling