TOPBP1 anticorps (C-Term)

N° du produit ABIN7452107

Détail du produit anti-TOPBP1 anticorps

Antigène: TOPBP1 (Topoisomerase (DNA) II Binding Protein 1 (TOPBP1))

Épitope: C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TOPBP1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Fonction: Rabbit anti-TopBP1 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: between AA 1400 and C-term

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur TOPBP1

Antigène: TOPBP1 (Topoisomerase (DNA) II Binding Protein 1 (TOPBP1))

Autre désignation: TopBP1 (TOPBP1 Produits)

Synonymes: anticorps RGD1562949, anticorps TOPBP1, anticorps cut5, anticorps F2P24.3, anticorps F2P24_3, anticorps meiosis defective 1, anticorps TOP2BP1, anticorps 1110031N14Rik, anticorps 2810429C13Rik, anticorps AI256758, anticorps D430026L04Rik, anticorps mKIAA0259, anticorps TopBP1-A, anticorps TopBP1-B, anticorps Xmus101, anticorps XtopBP, anticorps mus101, anticorps top2bp1, anticorps DNA topoisomerase II binding protein 1, anticorps topoisomerase (DNA) II binding protein 1, anticorps dna topoisomerase ii binding protein 1 (IC), anticorps transcription coactivator, anticorps DNA topoisomerase II binding protein 1 L homeolog, anticorps Topbp1, anticorps topbp1, anticorps TOPBP1, anticorps MEI1, anticorps topbp1.L

Sujet: Background: Topoisomerases regulate topological states of DNA. DNA topoisomerase II-binding protein 1 (TopBP1) is a protein that interacts with the C-terminal region of topoisomerase II beta (Topo II beta). TopBP1 function has been found to be important to various aspects of cellular growth control such as DNA replication, the DNA damage checkpoint, and cell survival. TopBP1 interacts with several proteins through its BRCA1 C-terminal (BRCT) motifs. TopBP1 interacts and inhibits E2F1 transcriptional activity through an Rb-independent mechanism that involves recruitment of the SWI/SNF chromatin-remodeling complex proteins Brg1 and Brm.

ID gène: 11073

NCBI Accession: NP_008958

UniProt: Q92547

Pathways: Chromatin Binding