SPEN anticorps (AA 3375-3425)

N° du produit ABIN7452220

Détail du produit anti-SPEN anticorps

Antigène: SPEN (Spen Homolog, Transcriptional Regulator (SPEN))

Épitope: AA 3375-3425

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPEN est non-conjugé

Application: Immunoprecipitation (IP)

Fonction: Rabbit anti-SHARP Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: between AA 3375 and 3425

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 5 μg/mg lysate

WB: Not recommended. ABIN7451040 can be used successfully for WB of enriched preparations (e.g. immunoprecipitated) SHARP.

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur SPEN

Antigène: SPEN (Spen Homolog, Transcriptional Regulator (SPEN))

Autre désignation: SHARP (SPEN Produits)

Synonymes: anticorps HIAA0929, anticorps MINT, anticorps RBM15C, anticorps SHARP, anticorps Mint, anticorps mKIAA0929, anticorps spen family transcriptional repressor, anticorps SPEN homolog, transcriptional regulator (Drosophila), anticorps SPEN, anticorps Spen

Sujet: Background: SHARP functions as a transcriptional repressor by interacting with proteins involved in deacetylation such as the NuRD (nucleosome remodeling) complex. SHARP can also repress transcription by interacting with corepressors such as SMRT/NCoR (silencing mediator for retinoid and thyroid receptors/nuclear receptor corepressor). SHARP is able to suppress transcription through the Notch/RBP-J signaling pathway by competing RBP-J binding with the intracellular domain of Notch.

ID gène: 23013

NCBI Accession: NP_055816

UniProt: Q96T58