CNOT1 anticorps (AA 1400-1450)

N° du produit ABIN7452794

Détail du produit anti-CNOT1 anticorps

Antigène: CNOT1 (CCR4-NOT Transcription Complex, Subunit 1 (CNOT1))

Épitope: AA 1400-1450

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CNOT1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Fonction: Rabbit anti-CNOT1 Antibody, Affinity Purified

Homologie: Zebrafish,X. tropicalis

Purification: Affinity Purified

Immunogène: between AA 1400 and 1450

Isotype: IgG

Information d'application

Indications d'application:

IP: 50 - 100 μL/mg lysate

WB: 1:10,000 - 1:25,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur CNOT1

Antigène: CNOT1 (CCR4-NOT Transcription Complex, Subunit 1 (CNOT1))

Autre désignation: CNOT1 (CNOT1 Produits)

Synonymes: anticorps CDC39, anticorps NOT1, anticorps NOT1H, anticorps 6030411K04Rik, anticorps AA815922, anticorps D830048B13, anticorps RGD1308009, anticorps GB18988, anticorps cdc39-like, anticorps im:7141761, anticorps kiaa1007l, anticorps wu:fc58h04, anticorps zgc:152902, anticorps CNOT1, anticorps not1, anticorps cdc39, anticorps not1h, anticorps ad-005, anticorps NV18106, anticorps CCR4-NOT transcription complex subunit 1, anticorps CCR4-NOT transcription complex, subunit 1, anticorps CNOT1, anticorps Cnot1, anticorps LOC412371, anticorps cnot1, anticorps LOC100114396

Sujet: Background: Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity. [taken from NCBI Entrez Gene (Gene ID: 23019)]. [taken from the Universal Protein Resource (UniProt) A5YKK6].

ID gène: 23019

UniProt: A5YKK6

Pathways: Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Stem Cell Maintenance