ERCC5 anticorps (AA 650-700)

N° du produit ABIN7453883

Détail du produit anti-ERCC5 anticorps

Antigène: ERCC5 (DNA Repair Protein Complementing XP-G Cells (ERCC5))

Épitope: AA 650-700

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERCC5 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Fonction: Rabbit anti-ERCC5/XPG Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: between AA 650 and 700

Isotype: IgG

Information d'application

Indications d'application:

IHC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur ERCC5

Antigène: ERCC5 (DNA Repair Protein Complementing XP-G Cells (ERCC5))

Autre désignation: ERCC5/XPG (ERCC5 Produits)

Synonymes: anticorps COFS3, anticorps ERCM2, anticorps UVDR, anticorps XPG, anticorps XPGC, anticorps cofs3, anticorps ercm2, anticorps uvdr, anticorps xpg, anticorps xpgc, anticorps Xpg, anticorps ERCC excision repair 5, endonuclease, anticorps excision repair cross-complementation group 5 L homeolog, anticorps excision repair cross-complementing rodent repair deficiency, complementation group 5, anticorps ERCC5, anticorps ercc5.L, anticorps Ercc5

Sujet: Background: ERCC5 is a single-stranded DNA endonuclease involved in DNA excision repair. ERCC5 is an important component of the nucleotide excision repair (NER) pathway which is critical to the repair of DNA lesions caused by exposure to UV light. Defects in ERCC5 are the cause of xeroderma pigmentosum, an autosomal recessive disease characterized by a hypersensitivity to sunlight and a high predisposition to cancer on UV-exposed areas.

ID gène: 2073

NCBI Accession: NP_000114

UniProt: P28715

Pathways: Réparation de l'ADN