UBR4 anticorps (AA 150-200)

N° du produit ABIN7454442

Détail du produit anti-UBR4 anticorps

Antigène: UBR4 (Ubiquitin Protein Ligase E3 Component N-Recognin 4 (UBR4))

Épitope: AA 150-200

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UBR4 est non-conjugé

Application: Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Fonction: Rabbit anti-p600 Antibody, Affinity Purified

Homologie: Mouse,Rat

Purification: Affinity Purified

Immunogène: between AA 150 and 200

Isotype: IgG

Information d'application

Indications d'application:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 10 μg/mg lysate

WB: Not recommended. Use rabbit anti-p600 antibody A302-278A or A302-279A.

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur UBR4

Antigène: UBR4 (Ubiquitin Protein Ligase E3 Component N-Recognin 4 (UBR4))

Autre désignation: p600 (UBR4 Produits)

Synonymes: anticorps ZUBR1, anticorps RBAF600, anticorps p600, anticorps 1810009A16Rik, anticorps A930005E13Rik, anticorps D930005K06Rik, anticorps Gm1032, anticorps Gm1666, anticorps N28143, anticorps Zubr1, anticorps mKIAA0462, anticorps Rbaf600, anticorps ubiquitin protein ligase E3 component n-recognin 4, anticorps E3 ubiquitin-protein ligase UBR4, anticorps UBR4, anticorps Ubr4, anticorps LOC100511934

Sujet: Background: p600 is an E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. It recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, p600 forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Additionally p600 regulates integrin-mediated signaling and may play a role in activation of FAK in response to cell-matrix interactions [taken from the Universal Protein Resource (UniProt) Q5T4S7].

ID gène: 23352

NCBI Accession: NP_065816

UniProt: Q5T4S7