Claspin anticorps (AA 725-775)

N° du produit ABIN7454603

Détail du produit anti-Claspin anticorps

Antigène: Claspin (CLSPN)

Épitope: AA 725-775

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Claspin est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Fonction: Rabbit anti-Claspin Antibody, Affinity Purified

Homologie: Orangutan,Gorilla,Chimpanzee

Purification: Affinity Purified

Immunogène: between AA 725 and 775

Isotype: IgG

Information d'application

Indications d'application:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 1 - 5 μg/mg lysate

WB: 1:500 - 1:2,500

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur Claspin

Antigène: Claspin (CLSPN)

Autre désignation: Claspin (CLSPN Produits)

Synonymes: anticorps CLSPN, anticorps xClaspin, anticorps B130025E01, anticorps C85083, anticorps E130314M08Rik, anticorps claspin, anticorps claspin S homeolog, anticorps Clspn, anticorps CLSPN, anticorps clspn, anticorps clspn.S

Sujet: Background: Claspin is a checkpoint protein that interacts with and regulates checkpoint kinase 1 (Chk1) in response to replication stress. The interaction between claspin and Chk1 has been demonstrated to be required for ATR-dependent Chk1 activation. The interaction involves the phosphorylation of claspin that may be accomplished by Chk1 kinase activity. Claspin has been found to localize to chromatin in both the presence and absence of damaged DNA and to associate with PCNA, as an essential component of the DNA replication machinery. This association with the replication machinery may indicate a role for claspin in linking replication to DNA damage signaling and Chk1 activation.

ID gène: 63967

UniProt: Q9HAW4