MAML2 anticorps (C-Term)

N° du produit ABIN7454661

Détail du produit anti-MAML2 anticorps

Antigène: MAML2 (Mastermind-Like 2 (MAML2))

Épitope: C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAML2 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Fonction: Rabbit anti-MAML2 Antibody, Affinity Purified

Homologie: Bovine

Purification: Affinity Purified

Immunogène: between AA 1100 and C-term

Isotype: IgG

Information d'application

Indications d'application:

IHC: 1:200 - 1:1,000. Epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.

IP: 1 - 4 μg/mg lysate

WB: 1:2,000 - 1:15,000

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur MAML2

Antigène: MAML2 (Mastermind-Like 2 (MAML2))

Autre désignation: MAML2 (MAML2 Produits)

Synonymes: anticorps 5930431H10, anticorps BC032967, anticorps MAM-3, anticorps MAM2, anticorps MAM3, anticorps MLL-MAML2, anticorps mastermind like 2 (Drosophila), anticorps mastermind-like transcriptional coactivator 2, anticorps mastermind like transcriptional coactivator 2, anticorps Maml2, anticorps MAML2

Sujet: Background: There are 3 MAML (mastermind-like) proteins in mammals (MAML1-3). MAML2 is a critical coactivator for NOTCH signaling. MAML2 associates with NOTCH and CSL in a ternary complex and functions to activate transcription of HES and hairy-related basic helix-loop-helix transcription factors. MAML2 has been identified in a chromosomal rearrangement and fusion with MECT1 in mucoepidermoid carcinomas, secondary acute myeloid leukemia, hidradenomas, and myelodysplastic syndrome. MECT1 is a CREB regulator, and when fused with the transactivational domain of MAML2, imparts constitutive activation of CREB-dependent transcription that may promote oncogenesis.

ID gène: 84441

UniProt: Q8IZL2