CDT2/RAMP anticorps (C-Term)

N° du produit ABIN7454696

Détail du produit anti-CDT2/RAMP anticorps

Antigène: CDT2/RAMP (DTL) (Denticleless E3 Ubiquitin Protein Ligase Homolog (DTL))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDT2/RAMP est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Fonction: Rabbit anti-DTL/CDT2 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: Between AA 680 and C-term

Isotype: IgG

Information d'application

Indications d'application:

IHC: 1:200 to 1:1000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur CDT2/RAMP

Antigène: CDT2/RAMP (DTL) (Denticleless E3 Ubiquitin Protein Ligase Homolog (DTL))

Autre désignation: DTL/CDT2 (DTL Produits)

Synonymes: anticorps CDT2, anticorps DCAF2, anticorps L2DTL, anticorps RAMP, anticorps 2810047L02Rik, anticorps 5730564G15Rik, anticorps Ramp, anticorps RGD1310439, anticorps cdt2, anticorps cdt2-a, anticorps dcaf2, anticorps l2dtl, anticorps ramp, anticorps cb151, anticorps chunp6871, anticorps wu:fb54b02, anticorps denticleless E3 ubiquitin protein ligase homolog, anticorps denticleless E3 ubiquitin protein ligase, anticorps denticleless E3 ubiquitin protein ligase homolog S homeolog, anticorps denticleless E3 ubiquitin protein ligase homolog (Drosophila), anticorps DTL, anticorps Dtl, anticorps dtl.S, anticorps dtl

Sujet: Background: DTL/CDT2 is a component of the CUL4A-DDB1 E3 ubiquitinating complex and plays a role in downregulating CDT1, an essential component of pre-replication complexes (Pre-RC) that ensures the genome is replicated only once per cycle. As part of the CUL4A-DDB1 E3 ligase complex DTL/CDT2 is also involved in the regulation of other proteins involved in the G2/M cell cycle checkpoint.

ID gène: 51514

NCBI Accession: NP_057532

UniProt: Q9NZJ0