AKAP8L anticorps (AA 596-646)

N° du produit ABIN7454742

Détail du produit anti-AKAP8L anticorps

Antigène: AKAP8L (A Kinase (PRKA) Anchor Protein 8-Like (AKAP8L))

Épitope: AA 596-646

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AKAP8L est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Fonction: Rabbit anti-AKAP8L/HA95 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: between AA 596 and 646

Isotype: IgG

Information d'application

Indications d'application:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur AKAP8L

Antigène: AKAP8L (A Kinase (PRKA) Anchor Protein 8-Like (AKAP8L))

Autre désignation: AKAP8L/HA95 (AKAP8L Produits)

Synonymes: anticorps HA95, anticorps HAP95, anticorps NAKAP, anticorps NAKAP95, anticorps Nakap95, anticorps zgc:85966, anticorps AKAP8L, anticorps A-kinase anchoring protein 8 like, anticorps A kinase (PRKA) anchor protein 8-like, anticorps A-kinase anchoring protein 8 like L homeolog, anticorps AKAP8L, anticorps Akap8l, anticorps akap8l, anticorps akap8l.L

Sujet: Background: AKAP8L/HA95 is a PKA anchoring protein that is localized to the nuclear envelope and associates with chromatin upon nuclear envelope breakdown during mitosis. AKAP8L/HA95 has been found to play an important role in the initiation of DNA replication and may function as a scaffold for proteins such as MCM2 and LAP2beta. Additionally, AKAP8L/HA95 has been shown to co-locate with the PKA C subunit in splicing factor compartments and is involved in the regulation of pre-mRNA splicing. Further support for a scaffolding and splicing role in the nucleus comes from the observation that AKAP8L/HA95 colocalizes with HypA, a splicing-like factor, and through this association may function as a docking site for the nuclear accumulation of Huntington protein as seen in Huntington's disease.

ID gène: 26993

NCBI Accession: NP_055186

UniProt: Q9ULX6

Pathways: SARS-CoV-2 Protein Interactome