COBRA1 anticorps (AA 530-580)

N° du produit ABIN7454796

Détail du produit anti-COBRA1 anticorps

Antigène: COBRA1 (Cofactor of BRCA1 (COBRA1))

Épitope: AA 530-580

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp COBRA1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Fonction: Rabbit anti-COBRA1 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: between AA 530 and 580

Isotype: IgG

Information d'application

Indications d'application:

IHC: 1:200 - 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur COBRA1

Antigène: COBRA1 (Cofactor of BRCA1 (COBRA1))

Autre désignation: COBRA1 (COBRA1 Produits)

Synonymes: anticorps LOC100219583, anticorps COBRA1, anticorps NELF-B, anticorps bZ1O1.4, anticorps cobra1, anticorps cobra2, anticorps fe01e12, anticorps wu:fe01e12, anticorps zgc:55628, anticorps MGC131073, anticorps Cobra1, anticorps RGD1307832, anticorps A730008L03Rik, anticorps AB041607, anticorps AI663983, anticorps Nelf-b, anticorps cofactor of BRCA1, anticorps negative elongation factor complex member B, anticorps negative elongation factor complex member B L homeolog, anticorps LOC100219583, anticorps NELFB, anticorps nelfb, anticorps nelfb.L, anticorps Nelfb

Sujet: Background: COBRA1 (Cofactor of BRCA1) is also known as NELFB (negative elongation factor E). NELFB is one of four subunits that make up the NELF transcription elongation factor. The four subunits of NELF are NELF A (WHSC2), NELFB, either NELFC or NELFD, and NELFE. NELF, along with DRB sensitivity-inducing factor (DSIF), functions to cause transcriptional pausing of RNA polymerase II. COBRA1 was originally identified in a yeast two-hybrid screen of a human ovary cDNA library using the BRCA COOH terminus repeat, BRCT1, as the bait protein. In this study, COBRA1 was found to be involved in BRCT1-mediated chromatin remodeling. COBRA1 has also been found to interact with several nuclear receptors such as ERalpha and androgen receptor to modulate their transcriptional activity.

ID gène: 25920

NCBI Accession: NP_056271

UniProt: Q8WX92