SENP3 anticorps (AA 275-325)

N° du produit ABIN7454900

Détail du produit anti-SENP3 anticorps

Antigène: SENP3 (SUMO/sentrin Specific Peptidase 3 (SENP3))

Épitope: AA 275-325

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SENP3 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Fonction: Rabbit anti-SENP3 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: between AA 275 and 325

Isotype: IgG

Information d'application

Indications d'application:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur SENP3

Antigène: SENP3 (SUMO/sentrin Specific Peptidase 3 (SENP3))

Autre désignation: SENP3 (SENP3 Produits)

Synonymes: anticorps SMT3IP1, anticorps SSP3, anticorps Ulp1, anticorps AA408656, anticorps Smt3ip, anticorps Smt3ip1, anticorps ssp3, anticorps smt3ip1, anticorps fa03d07, anticorps wu:fa03d07, anticorps senp3, anticorps SUMO1/sentrin/SMT3 specific peptidase 3, anticorps SUMO/sentrin specific peptidase 3, anticorps Sumo1/sentrin/SMT3 specific peptidase 3, anticorps SUMO1/sentrin/SMT3 specific peptidase 3b, anticorps SUMO1/sentrin/SMT3 specific peptidase 3 L homeolog, anticorps SENP3, anticorps Senp3, anticorps senp3, anticorps senp3b, anticorps senp3.L

Sujet: Background: Sentrin-specific protease 3 (SENP3) functions as a protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates.SENP3 deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability, and also deconjugates SUMO2 and SUMO3 from CDCA8. SENP3 can function as a redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. SENP3 is required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 [taken from the Universal Protein Resource (UniProt) Q9H4L4].

ID gène: 26168

NCBI Accession: NP_056485

UniProt: Q9H4L4