Recombinant UBQLN4 anticorps (AA 2-601)

N° du produit ABIN7455161

Détail du produit anti-UBQLN4 anticorps

Antigène: UBQLN4 (Ubiquilin 4 (UBQLN4))

Type d'anticorp: Recombinant Antibody

Épitope: AA 2-601

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp UBQLN4 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Fonction: Rabbit anti-UBQLN4/CIP75/Ubiquilin 4 Recombinant Monoclonal Antibody [BLR145J]

Immunogène: residues 2-601 (full length)

Clone: BLR145J

Isotype: IgG

Information d'application

Indications d'application:

IHC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 20 μL/1 mg lysate

ICC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections.

WB: 01:01,00

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: Borate Buffered Saline (BBS) pH 8.2 with 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur UBQLN4

Antigène: UBQLN4 (Ubiquilin 4 (UBQLN4))

Autre désignation: UBQLN4/CIP75/Ubiquilin 4 (UBQLN4 Produits)

Synonymes: anticorps a1u, anticorps cip75, anticorps ubin, anticorps ubiquilin-4, anticorps A1U, anticorps A1Up, anticorps C1orf6, anticorps CIP75, anticorps UBIN, anticorps A1u, anticorps AI663987, anticorps RGD1308273, anticorps ubiquilin 4 L homeolog, anticorps ubiquilin 4, anticorps ubqln4.L, anticorps ubqln4, anticorps UBQLN4, anticorps Ubqln4

Sujet: Background: Ubiquilin-4 (UBQLN4) plays a role in the regulation of protein degradation via the ubiquitin-proteasome system (UPS). It mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. UBQLN4 Plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). It acts as an adapter protein that recruits UBQLN1 to the autophagy machinery and mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205) [taken from NCBI Entrez Gene (Gene ID: 56893)].

ID gène: 56893

NCBI Accession: NP_064516

UniProt: Q9NRR5