TET1 anticorps

N° du produit ABIN7464226

Détail du produit anti-TET1 anticorps

Antigène: TET1 (Tet Methylcytosine Dioxygenase 1 (TET1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TET1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Réactivité croisée: Humain, Souris

Purification: Affinity purified by Protein G.

Classe de qualité: KO Validated

Immunogène: Recombinant protein encompassing a sequence within the center region of human TET1. The exact sequence is proprietary.

Clone: GT1462

Isotype: IgG2b

Information d'application

Indications d'application: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: 293T , DDDDK-human TET1-transfected 293T cells , NT2D1 nuclear extract

Validation: KO/KD, Orthogonal, Overexpression

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, No Preservative

Agent conservateur: Without preservative

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur TET1

Antigène: TET1 (Tet Methylcytosine Dioxygenase 1 (TET1))

Autre désignation: tet methylcytosine dioxygenase 1 (TET1 Produits)

Synonymes: anticorps CXXC6, anticorps LCX, anticorps bA119F7.1, anticorps 2510010B09Rik, anticorps AA517754, anticorps BB001228, anticorps Cxxc6, anticorps D10Ertd17e, anticorps mKIAA1676, anticorps tet methylcytosine dioxygenase 1, anticorps solute carrier family 25 member 16, anticorps TET1, anticorps Tet1, anticorps SLC25A16

Sujet: Tet methylcytosine dioxygenase 1 , CXXC6 , LCX , bA119F7.1,Dioxygenase that specifically binds methylcytosine (5mC), a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. Catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. 5-hydroxymethylcytosine (hmC) is present in ES cells and is enriched in the brain, especially in Purkinje neurons. May play a role in the fetal development of heart, lung and brain.

Poids moléculaire: 235 kDa

ID gène: 80312

UniProt: Q8NFU7

Pathways: Stem Cell Maintenance, L'effet Warburg