TDG anticorps (N-Term)

N° du produit ABIN7464910

Détail du produit anti-TDG anticorps

Antigène: TDG (Thymine-DNA Glycosylase (TDG))

Épitope: N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TDG est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Humain, Rat

Purification: Purified by antigen-affinity chromatography.

Classe de qualité: KO Validated

Immunogène: Recombinant protein encompassing a sequence within the N-terminus region of human TDG. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:5000-1:20000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: rat brain , HeLa , TDG-transfected 293T

Validation: KO/KD, Overexpression

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur TDG

Antigène: TDG (Thymine-DNA Glycosylase (TDG))

Autre désignation: thymine DNA glycosylase (TDG Produits)

Synonymes: anticorps 5-MCDG, anticorps wu:fb44b11, anticorps zgc:110622, anticorps MGC82456, anticorps MGC89441, anticorps E130317C12Rik, anticorps JZA-3, anticorps Jza1, anticorps hTDG, anticorps thymine DNA glycosylase, anticorps thymine DNA glycosylase, tandem duplicate 1, anticorps putative g/t mismatch-specific thymine DNA glycosylase, anticorps G/T mismatch-specific thymine DNA glycosylase, anticorps thymine DNA glycosylase S homeolog, anticorps thymine-DNA glycosylase, anticorps TDG, anticorps tdg.1, anticorps Smp_149220, anticorps Tsp_05734, anticorps tdg.S, anticorps tdg, anticorps Tdg

Sujet: Thymine DNA glycosylase , hTDG,The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq]

Poids moléculaire: 46 kDa

ID gène: 6996

UniProt: Q13569

Pathways: Réparation de l'ADN, Chromatin Binding