USP20 anticorps
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- Antigène Voir toutes USP20 Anticorps
- USP20 (Ubiquitin Specific Peptidase 20 (USP20))
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp USP20 est non-conjugé
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Application
- Western Blotting (WB)
- Réactivité croisée
- Humain
- Purification
- Affinity purified by Protein A.
- Immunogène
- Recombinant protein encompassing a sequence within the center region of human USP20. The exact sequence is proprietary.
- Isotype
- IgG
- Top Product
- Discover our top product USP20 Anticorps primaire
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- Indications d'application
- WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- Commentaires
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Positive Control: 293T , Raji
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.98 mg/mL
- Buffer
- 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- Antigène
- USP20 (Ubiquitin Specific Peptidase 20 (USP20))
- Autre désignation
- ubiquitin specific peptidase 20 (USP20 Produits)
- Synonymes
- anticorps USP20, anticorps vdu2, anticorps lsfr3a, anticorps LSFR3A, anticorps VDU2, anticorps hVDU2, anticorps 1700055M05Rik, anticorps AI467231, anticorps Vdu2, anticorps im:7151955, anticorps zgc:63661, anticorps universal stress protein, anticorps ubiquitin specific peptidase 20, anticorps ubiquitin specific peptidase 20 L homeolog, anticorps RR_RS15875, anticorps USP20, anticorps usp20, anticorps Usp20, anticorps usp20.L
- Sujet
- Ubiquitin specific peptidase 20 , LSFR3A , VDU2 , hVDU2,Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
- Poids moléculaire
- 102 kDa
- ID gène
- 10868
- UniProt
- Q9Y2K6
- Pathways
- Regulation of G-Protein Coupled Receptor Protein Signaling
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