RFWD3 anticorps (C-Term)

N° du produit ABIN7466618

Détail du produit anti-RFWD3 anticorps

Antigène: RFWD3 (Ring Finger and WD Repeat Domain 3 (RFWD3))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RFWD3 est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Humain

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the C-terminus region of human RFWD3. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: MCF-7

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.96 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur RFWD3

Antigène: RFWD3 (Ring Finger and WD Repeat Domain 3 (RFWD3))

Autre désignation: ring finger and WD repeat domain 3 (RFWD3 Produits)

Synonymes: anticorps RGD1305243, anticorps RFWD3, anticorps RNF201, anticorps BC027246, anticorps ring finger and WD repeat domain 3, anticorps Rfwd3, anticorps RFWD3

Sujet: Ring finger and WD repeat domain 3 , FANCW , RNF201,E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53.

Poids moléculaire: 85 kDa

ID gène: 55159

UniProt: Q6PCD5