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PHAX anticorps

PHAX Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7469234
  • Antigène Voir toutes PHAX Anticorps
    PHAX (phosphorylated Adaptor For RNA Export (PHAX))
    Reactivité
    • 36
    • 6
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 1
    Humain
    Hôte
    • 36
    Lapin
    Clonalité
    • 36
    Polyclonal
    Conjugué
    • 16
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PHAX est non-conjugé
    Application
    • 26
    • 20
    • 13
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
     Réactivité croisée
    Humain
    Purification
    Purified by antigen-affinity chromatography.
    Immunogène
    Recombinant protein encompassing a sequence within the center region of human PHAX. The exact sequence is proprietary.
    Isotype
    IgG
    Top Product
    Discover our top product PHAX Anticorps primaire
  • Indications d'application
    WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Commentaires

    Positive Control: 293T

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal
    Agent conservateur
    Thimerosal (Merthiolate)
    Précaution d'utilisation
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Antigène
    PHAX (phosphorylated Adaptor For RNA Export (PHAX))
    Autre désignation
    PHAX (PHAX Produits)
    Synonymes
    anticorps RNUXA, anticorps 2810055C14Rik, anticorps 4933427L19Rik, anticorps AU018701, anticorps AU018854, anticorps D18Ertd65e, anticorps Rnuxa, anticorps p55, anticorps phosphorylated adaptor for RNA export, anticorps PHAX, anticorps Phax
    Sujet

    Synonyms: phosphorylated adaptor for RNA export , RNUXA

    Background: A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA.

    Poids moléculaire
    44 kDa
    ID gène
    51808
    UniProt
    Q9H814
    Pathways
    Ribonucleoprotein Complex Subunit Organization
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