UPF3B anticorps
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- Antigène Voir toutes UPF3B Anticorps
- UPF3B (UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B))
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp UPF3B est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Réactivité croisée
- Humain
- Purification
- Purified by antigen-affinity chromatography.
- Immunogène
- Recombinant protein encompassing a sequence within the center region of human UPF3B. The exact sequence is proprietary.
- Isotype
- IgG
- Top Product
- Discover our top product UPF3B Anticorps primaire
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- Indications d'application
- WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- Commentaires
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Positive Control: 293T , A431 , HeLa , HepG2
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1.27 mg/mL
- Buffer
- 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- Antigène
- UPF3B (UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B))
- Autre désignation
- UPF3B (UPF3B Produits)
- Synonymes
- anticorps HUPF3B, anticorps MRXS14, anticorps RENT3B, anticorps UPF3X, anticorps 5730594O13Rik, anticorps AI317193, anticorps AW541158, anticorps RGD1560264, anticorps UPF3B, regulator of nonsense mediated mRNA decay, anticorps UPF3 regulator of nonsense transcripts homolog B (yeast), anticorps UPF3B, anticorps Upf3b
- Sujet
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Synonyms: UPF3B regulator of nonsense mediated mRNA decay , HUPF3B , MRX62 , MRXS14 , RENT3B , UPF3BP1 , UPF3BP2 , UPF3BP3 , UPF3X , Upf3p-X
Background: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq]
- Poids moléculaire
- 58 kDa
- ID gène
- 65109
- UniProt
- Q9BZI7
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