The mouse monoclonal antibody 9E8 recognizes an extracellular epitope of human CD367, a type II transmembrane protein of C-lectin family, expressed mainly on antigen presenting cells.
anticorps CLEC4A, anticorps CLECSF6, anticorps DCIR, anticorps DDB27, anticorps LLIR, anticorps Clecsf6, anticorps Dcir1, anticorps Clec4a, anticorps zinc finger protein 705A, anticorps C-type lectin domain family 4 member A, anticorps C-type lectin domain family 4, member A, anticorps C-type lectin domain family 4, member a2, anticorps ZNF705A, anticorps CLEC4A, anticorps Clec4a, anticorps Clec4a2
Sujet
C-type lectin domain family 4 member A,CD367 is an approximately 20-28 kDa C-type lectin with immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic part. CD367 binds in calcium-dependent manner to mannose, fucose, and weakly also to N-acetylglucosamine. It is expressed on dendritic cells, macrophages, monocytes, B cells, and neutrophils. In rheumatoid arthitis patients CD367 is expressed also on CD4+ T cells. After ligand-mediated triggering, it is internalized by clathrin-dependent endocytosis and contributes to the antigen presentation to CD8+ T cells. It may also be involved in modulation of the antigen presenting cell response.,DCIR, CLEC4A, LLIR