Recombinant SIRPG anticorps

N° du produit ABIN7543054

Détail du produit anti-SIRPG anticorps

Antigène: SIRPG (Signal-Regulatory Protein gamma (SIRPG))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SIRPG est non-conjugé

Application: ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP), Blocking Reagent (BR)

Fonction: Anti-SIRP g [OX-119], Mouse IgG1, kappa

Specificité: Hybridoma supernatants were initially screened by ELISA, using SIRPg-CD4, human SIRPa-Fc, human SIRPb-Fc or CD4 to eliminate hybridomas with cross-reactivity to rat CD4, human SIRPa, and SIRPb. There is some marginal binding of OX-119 to SIRPb transfected 293T cells. SIRPg binds CD47. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells..

Attributs du produit:

Original Species of Ab: Mouse

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Immunogène: OX-119 was prepared by immunizing BALB/c mice with a chimeric protein made up of human SIRPg and a leader peptide of rat CD4 domain (SIRPg-CD4 ).

Clone: OX-119

Isotype: IgG1 kappa

Information d'application

Indications d'application: OX-119 is able to perform staining of peripheral blood myeloid cells (PBMCs) and block SIRPg-mediated apoptosis. OX-119 can also be used in IP, FC and ELISA.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur SIRPG

Antigène: SIRPG (Signal-Regulatory Protein gamma (SIRPG))

Autre désignation: SIRP g (SIRPG Produits)

Sujet: CD172g, OX119, MRC OX-119, MRC OX119, SIRP-g, SIRPg, SIRP gamma, SIRP-gamma, CD172 antigen-like family member B, signal-regulatory protein beta, CD172-g

UniProt: Q9P1W8