ESR2 anticorps (AA 201-300)

N° du produit ABIN725210

Détail du produit anti-ESR2 anticorps

Antigène: ESR2 (Estrogen Receptor 2 (ESR2))

Épitope: AA 201-300

Reactivité: Humain, Souris, Rat, Mouton

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ESR2 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Souris, Rat, Mouton

Homologie: Cow,Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ER-beta

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-ESR2 (ABIN725210)

Wei, Guo, Mu, Zhang, Zhao, Huai, Qiu, Li, Ma, Liu, Chen, Han: "Estrogen suppresses hepatocellular carcinoma cells through ERβ-mediated upregulation of the NLRP3 inflammasome." dans: Laboratory investigation; a journal of technical methods and pathology, Vol. 95, Issue 7, pp. 804-16, (2015) (PubMed).

Fang, Wu, Huang: "Raloxifene upregulated mesangial cell MMP-2 activity via ER-? through transcriptional regulation." dans: Cell biochemistry and biophysics, Vol. 67, Issue 2, pp. 607-13, (2013) (PubMed).

Détails sur ESR2

Antigène: ESR2 (Estrogen Receptor 2 (ESR2))

Autre désignation: Estrogen receptor beta (ESR2 Produits)

Synonymes: anticorps ER-BETA, anticorps ESR-BETA, anticorps ESRB, anticorps ESTRB, anticorps Erb, anticorps NR3A2, anticorps ER[b]1, anticorps zfER-beta1, anticorps zfER[b]1, anticorps erb2, anticorps CERB, anticorps ERB, anticorps erb, anticorps esrb, anticorps estrb, anticorps nr3a2, anticorps ERbeta, anticorps er-beta, anticorps esr-beta, anticorps ESR2, anticorps ERBETA, anticorps er, anticorps ER-beta, anticorps ER[b], anticorps Estrb, anticorps ER[b]2, anticorps ER[b]a, anticorps zfER[b]2, anticorps zfER-beta2, anticorps Erb2, anticorps esr2, anticorps erbeta, anticorps Esr2, anticorps ERBeta2, anticorps estrogen receptor 2, anticorps estrogen receptor 2b, anticorps estrogen receptor beta 2, anticorps estrogen receptor 2 (beta), anticorps estrogen receptor 2a, anticorps estrogen receptor beta, anticorps ESR2, anticorps esr2b, anticorps erb2, anticorps esr2, anticorps Esr2, anticorps esr2a, anticorps erbeta

Sujet:

Synonyms: Erb, ESRB, ESTRB, NR3A2, ER-BETA, ESR-BETA, Estrogen receptor beta, Nuclear receptor subfamily 3 group A member 2, ESR2

Background: Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.

ID gène: 2100

UniProt: Q92731

Pathways: Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling