IRS2 anticorps (AA 501-600)

N° du produit ABIN725840

Détail du produit anti-IRS2 anticorps

Antigène: IRS2 (Insulin Receptor Substrate 2 (IRS2))

Épitope: AA 501-600

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IRS2 est non-conjugé

Application: ELISA, Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human IRS-2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-IRS2 (ABIN725840)

Wang, Wang, Zhang, Lin, Liu, Xiao, Xiao, Wang: "Defective insulin signaling and the protective effects of dimethyldiguanide during follicular development in the ovaries of polycystic ovary syndrome." dans: Molecular medicine reports, Vol. 16, Issue 6, pp. 8164-8170, (2017) (PubMed).

Ling, Xie, Li, Liu, Cao, Yang, Wang, Hu, Xu, Zheng: "Donor Graft MicroRNAs: A Newly Identified Player in the Development of New-onset Diabetes After Liver Transplantation." dans: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, Vol. 17, Issue 1, pp. 255-264, (2016) (PubMed).

Détails sur IRS2

Antigène: IRS2 (Insulin Receptor Substrate 2 (IRS2))

Autre désignation: IRS-2 (IRS2 Produits)

Synonymes: anticorps IRS2, anticorps si:dkeyp-24d6.1, anticorps IRS-2, anticorps 4PS, anticorps Irs-2, anticorps insulin receptor substrate 2, anticorps insulin receptor substrate 2a, anticorps insulin receptor substrate 2b, anticorps IRS2, anticorps irs2a, anticorps irs2b, anticorps Irs2

Sujet:

Synonyms: IRS-2, Insulin receptor substrate 2, IRS2

Background: The family of insulin receptor substrates (IRSs) has been reported to play important roles for signal transduction of various hormones. Four members of the IRS family have been described. Each IRS is believed to have different functions, however, the distinct physiological roles of each IRS are unclear. Summary: This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.

ID gène: 8660

UniProt: Q9Y4H2

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process