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Retinoic Acid Receptor alpha anticorps (AA 361-462)

RARA Reactivité: Humain, Rat ELISA, IHC (p), IF (cc), IF (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN726860
  • Antigène Voir toutes Retinoic Acid Receptor alpha (RARA) Anticorps
    Retinoic Acid Receptor alpha (RARA) (Retinoic Acid Receptor, alpha (RARA))
    Épitope
    • 14
    • 11
    • 11
    • 8
    • 6
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 361-462
    Reactivité
    • 89
    • 38
    • 38
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain, Rat
    Hôte
    • 75
    • 17
    • 1
    Lapin
    Clonalité
    • 69
    • 24
    Polyclonal
    Conjugué
    • 53
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Retinoic Acid Receptor alpha est non-conjugé
    Application
    • 62
    • 41
    • 38
    • 21
    • 14
    • 12
    • 12
    • 11
    • 10
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
     Réactivité croisée
    Humain, Rat
    Homologie
    Mouse
    Purification
    Purified by Protein A.
    Immunogène
    OVA conjugated synthetic peptide derived from mouse Retinoic acid Receptor Alpha
    Isotype
    IgG
    Top Product
    Discover our top product RARA Anticorps primaire
  • Indications d'application
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Antigène
    Retinoic Acid Receptor alpha (RARA) (Retinoic Acid Receptor, alpha (RARA))
    Autre désignation
    RAR alpha (RARA Produits)
    Synonymes
    anticorps NR1B1, anticorps RAR, anticorps Nr1b1, anticorps RARalpha1, anticorps rar-alpha, anticorps etID309833.12, anticorps rara, anticorps rara2a, anticorps zRAR, anticorps zRAR-alpha, anticorps zgc:109797, anticorps nr1b1, anticorps RAR-ALPHA1, anticorps HS-RARa, anticorps fj66e06, anticorps rara2b, anticorps wu:fj66e06, anticorps retinoic acid receptor alpha, anticorps retinoic acid receptor, alpha, anticorps retinoic acid receptor, alpha a, anticorps retinoic acid receptor alpha L homeolog, anticorps retinoic acid receptor, alpha b, anticorps RARA, anticorps Rara, anticorps LOC100136372, anticorps raraa, anticorps rara.L, anticorps rara, anticorps rarab
    Sujet

    Synonyms: RAR, Nr1b1, RARalpha1, Retinoic acid receptor alpha, RAR-alpha, Nuclear receptor subfamily 1 group B member 1, Rara

    Background: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.

    ID gène
    19401
    UniProt
    P11416
    Pathways
    Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, S100 Proteins
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