Fibulin 1 anticorps (AA 501-600)

N° du produit ABIN728458

Détail du produit anti-Fibulin 1 anticorps

Antigène: Fibulin 1 (FBLN1)

Épitope: AA 501-600

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Fibulin 1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Réactivité croisée: Humain, Rat

Homologie: Mouse,Dog,Cow,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Fibulin 1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-Fibulin 1 (ABIN728458)

Angenendt, Reuter, Kentrup, Benk, Neumann, Hüve, Martens, Schwöppe, Kessler, Schmidt, Sauer, Brand, Mikesch, Lenz, Mesters, Müller-Tidow, Hartmann, Wardelmann, Neri, Berdel, Roesli, Schliemann: "An atlas of bloodstream-accessible bone marrow proteins for site-directed therapy of acute myeloid leukemia." dans: Leukemia, Vol. 32, Issue 2, pp. 510-519, (2017) (PubMed).

Détails sur Fibulin 1

Antigène: Fibulin 1 (FBLN1)

Autre désignation: Fibulin 1 (FBLN1 Produits)

Synonymes: anticorps fbln1, anticorps FBLN, anticorps FIBL1, anticorps fbln1c, anticorps fbln1d, anticorps wu:fc52c06, anticorps MGC115035, anticorps fibulin 1, anticorps fibulin 1 L homeolog, anticorps FBLN1, anticorps fbln1, anticorps Fbln1, anticorps fbln1.L, anticorps CpipJ_CPIJ017419

Sujet:

Synonyms: Basement membrane protein 90, BM 90, FBLN, FBLN1, FIBL 1, FIBL1, Fibulin 1.

Background: Fibulin-1 is an extracellular matrix protein often associated with fibronectin (FN) in vivo. Fibulin-1 was found to have pronounced inhibitory effects on the cell attachment and spreading promoted by FN. Fibulin-1 was also found to inhibit the motility of a variety of cell types on FN substrata. For example, the FN-dependent haptotactic motility of breast carcinoma (MDA MB231) cells, epidermal carcinoma (A431), melanoma (A375 SM), rat pulmonary aortic smooth muscle cells (PAC1) and Chinese hamster ovary (CHO) cells was inhibited by the presence of fibulin-1 bound to FN-coated Boyden chamber membranes. Cells transfected to overproduce fibulin-1 displayed reduced velocity, distance of movement and persistence time on FN substrata. Similarly, the incorporation of fibulin-1 into FN-containing type I collagen gels inhibited the invasion of endocardial cushion mesenchymal cells migrating from cultured embryonic heart explants. By contrast, incorporation of fibulin-1 into collagen gels lacking FN had no effect on the migration of endocardial cushion cells.

ID gène: 2192