Glutathione Reductase anticorps (AA 421-522)

N° du produit ABIN728848

Détail du produit anti-Glutathione Reductase anticorps

Antigène: Glutathione Reductase (GSR)

Épitope: AA 421-522

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Glutathione Reductase est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Souris

Homologie: Rat,Dog,Cow,Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human GSR

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-Glutathione Reductase (ABIN728848)

Khan, Li, Ahmad Khan, Rasul, Nawaz, Sun, Zheng, Ma: "Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction." dans: BioMed research international, Vol. 2013, pp. 719858, (2013) (PubMed).

Détails sur Glutathione Reductase

Antigène: Glutathione Reductase (GSR)

Autre désignation: GLUR/glutathione reductase (GSR Produits)

Synonymes: anticorps GR, anticorps ATGR2, anticorps EMB2360, anticorps glutathione reductase, anticorps AI325518, anticorps D8Ertd238e, anticorps Gr-1, anticorps Gr1, anticorps DDBDRAFT_0168952, anticorps DDBDRAFT_0231410, anticorps DDB_0168952, anticorps DDB_0231410, anticorps 2151, anticorps CG2151, anticorps DTR, anticorps Dm-TrxR, anticorps DmTR, anticorps DmTrx, anticorps DmTrxR, anticorps DmTrxR-1, anticorps Dmel\\CG2151, anticorps Gr, anticorps Trx, anticorps TrxR, anticorps TrxR-1, anticorps Trxr1, anticorps anon-WO03040301.185, anticorps anon-WO03040301.187, anticorps dTrxR, anticorps dmtrxr-1, anticorps gr, anticorps l(1)G0154, anticorps l(1)G0379, anticorps l(1)G0477, anticorps l(1)G0481, anticorps trxr-1, anticorps gor1, anticorps glutathione reductase, gro-2, anticorps glutathione reductase, anticorps glutathione-disulfide reductase, anticorps GR; GRase, anticorps mitochondrial glutathione reductase Pgr1, anticorps Glutathione reductase (GR) (GRase), anticorps Thioredoxin reductase-1, anticorps glutathione-disulfide reductase family protein, anticorps glutathione reductase 1, anticorps GR, anticorps gor, anticorps GSR, anticorps GSR1, anticorps Gsr_2, anticorps Gsr, anticorps GSHR1, anticorps gsr, anticorps LbGR, anticorps pgr1, anticorps GSHR2, anticorps GLR2, anticorps Bcen_2392, anticorps RPE_1989, anticorps HCAG_02219, anticorps SJAG_01162, anticorps Trxr-1, anticorps PF14_0192, anticorps POPTR_0001s14480g, anticorps gsr1

Sujet:

Synonyms: glutathione reductase, GLUR, Glutathione reductase mitochondrial, GR, Gr1, GRase, GRD 1, GRD1, GSR, MGC78522.

Background: Glutathione reductase (GR) is a member of pyridine nucleotide- disulfideoxidoreductases, which includes the closely related enzymes thioredoxin reductase, lipoamide dehydrogenase, trypanothione reductase and mercuric ion reductase. GR is a cytoplasmic flavoenzyme widely distributed in aerobic organisms. The dimeric protein is composed of two identical subunits, each containing 1 FAD and 1 redox-active disulfide/dithiol as components of the catalytic apparatus. It plays a role in maintaining glutathione (GSH) in its reduced form by catalyzing the reduction of glutathione disulfide (GSSG): GSSG + NADPH + H+?2GSH + NADP+. In mosteukaryotic cells, GR maintains the ratio of [GSH]/[GSSG], and participates in several vital functions such as the detoxification of reactive oxygen species as well as protein and DNA biosynthesis.

ID gène: 2890

Pathways: Thyroid Hormone Synthesis, Cell RedoxHomeostasis